期刊
NEURON
卷 106, 期 5, 页码 830-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2020.02.035
关键词
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资金
- European Research Council [ERC-2017-ADG-789128, ERC-2015-CoG-682422]
- European Union [323945]
- Deutsche Forschungsgemeinschaft [SFB 1315, FOR 2143]
- Thyssen Foundation
- Helmholtz Society
Humans detect skin temperature changes that are perceived as warm or cool. Like humans, mice report forepaw skin warming with perceptual thresholds of less than 1 degrees C and do not confuse warm with cool. We identify two populations of polymodal C-fibers that signal warm. Warm excites one population, whereas it suppresses the ongoing cool-driven firing of the other In the absence of the thermosensitive TRPM2 or TRPV1 ion channels, warm perception was blunted, but not abolished. In addition, trpv1:trpa1:trpm3(-/-) triple-mutant mice that cannot sense noxious heat detected skin warming, albeit with reduced sensitivity. In contrast, loss or local pharmacological silencing of the cool-driven TRPM8 channel abolished the ability to detect warm. Our data are not reconcilable with a labeled line model for warm perception, with receptors firing only in response to warm stimuli, but instead support a conserved dual sensory model to unambiguously detect skin warming in vertebrates.
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