期刊
CHEMICAL RECORD
卷 16, 期 6, 页码 2561-2572出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201600073
关键词
alkenes; amination; oxidation; reductive elimination; palladium
资金
- Deutsche Forschungsgemeinschaft (DFG)
- Fonds der Chemischen Industrie
- Agence Nationale de la Recherche (ANR)
- Ministerio de Economia y Competitividad (MINECO)
- MINECO
- FEDER [CTQ2014-56474R]
- ICREA Funding Source: Custom
Our interest in the development of transition-metal catalysis for the realisation of vicinal diamination reactions of alkenes started about a decade ago. A number of successful transformations in this area have been developed using palladium catalysis. As a challenging aspect of major importance, the palladium-catalysed coupling of alkyl-nitrogen bonds constitutes the second step in diaminations of alkenes. We here discuss the details that led us to consider high-oxidation-state palladium catalysis as a key feature in such C-N bond-forming reactions. This work discusses both our own contributions and the ones from colleagues and combines the discussion of catalytic reactions and stoichiometric control experiments. It demonstrates that reductive alkyl-nitrogen bond formation from palladium(IV) proceeds with a low activation barrier and through a linear transition state of nucleophilic displacement.
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