期刊
NEUROLOGY
卷 94, 期 20, 页码 E2088-E2098出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000009436
关键词
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资金
- National Institute on Aging [RF1 AG0151550, R01AG046171, U24 AG21886, U01AG024904-09S4, P50NS053488, R01AG19771, P30AG10133, P30AG10124, R03AG054936, K01AG049050]
- ADNI (NIH grant) [U01 AG024904]
- Department of Defense ADNI (Department of Defense award) [W81XWH-12-2-0012]
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc
- Biogen
- Bristol-Myers Squibb Co
- CereSpir, Inc
- Cogstate
- Eisai Inc
- Elan Pharmaceuticals, Inc
- Eli Lilly and Co
- EuroImmun
- F. Hoffmann-La Roche Ltd
- Genentech, Inc
- Fujirebio
- GE Healthcare
- IXICO Ltd
- Janssen Alzheimer Immunotherapy Research & Development, LLC
- Johnson & Johnson Pharmaceutical Research & Development LLC
- Lumosity
- Lundbeck
- Merck Co, Inc
- Meso Scale Diagnostics, LLC
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corp
- Pfizer Inc
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Co
- Transition Therapeutics
- Canadian Institutes of Health Research
- National Library of Medicine [R01LM011360, R01 LM012535]
- National Institute of Biomedical Imaging and Bioengineering [R01EB022574]
- Indiana Clinical and Translational Science Institute
- Indiana University-IU Health Strategic Neuroscience Research Initiative
- Indiana Clinical and Translational Sciences Institute from NIH [UL1TR002529]
- National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award
- National Institute on Aging of the NIH [F30AG063449]
ObjectiveTo investigate the association of triglyceride (TG) principal component scores with Alzheimer disease (AD) and the amyloid, tau, neurodegeneration, and cerebrovascular disease (A/T/N/V) biomarkers for AD.MethodsSerum levels of 84 TG species were measured with untargeted lipid profiling of 689 participants from the Alzheimer's Disease Neuroimaging Initiative cohort, including 190 cognitively normal older adults (CN), 339 with mild cognitive impairment (MCI), and 160 with AD. Principal component analysis with factor rotation was used for dimension reduction of TG species. Differences in principal components between diagnostic groups and associations between principal components and AD biomarkers (including CSF, MRI and [F-18]fluorodeoxyglucose-PET) were assessed with a generalized linear model approach. In both cases, the Bonferroni method of adjustment was used to correct for multiple comparisons.ResultsThe 84 TGs yielded 9 principal components, 2 of which, consisting of long-chain, polyunsaturated fatty acid-containing TGs (PUTGs), were significantly associated with MCI and AD. Lower levels of PUTGs were observed in MCI and AD compared to CN. PUTG principal component scores were also significantly associated with hippocampal volume and entorhinal cortical thickness. In participants carrying the APOE epsilon 4 allele, these principal components were significantly associated with CSF beta -amyloid(1-42) values and entorhinal cortical thickness.ConclusionThis study shows that PUTG component scores were significantly associated with diagnostic group and AD biomarkers, a finding that was more pronounced in APOE epsilon 4 carriers. Replication in independent larger studies and longitudinal follow-up are warranted.
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