期刊
NEUROIMAGE
卷 212, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2020.116601
关键词
Task-based fMRI; Replicability; Reproducibility; Reliability; Stability; Coherence
资金
- Research Foundation Flanders (FWO) [G.0149.14N]
- European Union [LSHM-CT-2007-037,286]
- Horizon 2020 [695313]
- ERANID (Understanding the Interplay between Cultural, Biological and Subjective Factors in Drug Use Pathways) [PRST-0416-10004]
- BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics) [MR/N027558/1]
- FP7 project IMAGEMEND [602450]
- FP7 project MATRICS [603016]
- Innovative Medicine Initiative Project EU-AIMS [115300-2]
- Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions) [MR/N000390/1]
- Swedish Research Council FORMAS
- Medical Research Council
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- Bundesministeriumfur Bildung und Forschung (BMBF) [01GS08152, 01EV0711, eMED SysAlc01ZX1311A, Forschungsnetz AERIAL 01EE1406A, 01EE1406B]
- Deutsche Forschungsgemeinschaft (DFG) [SM 80/7-2, SFB 940/2]
- Medical Research Foundation [MR/R00465X/1]
- Medical research council [MR/R00465X/1]
- Human Brain Project (HBP SGA 2)
- ANR [AF12-NEUR0008-01 WM2NA, ANR-12-SAMA-0004]
- Fondation de France
- Fondation pour la Recherche Medicale
- Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA)
- Assistance-Publique-Hopitaux-de-Paris
- INSERM
- Paris Sud University IDEX 2012
- National Institutes of Health
- Science Foundation Ireland [16/ERCD/3797]
- U.S.A. (Axon, Testosterone and Mental Health during Adolescence) [RO1 MH085772-01A1]
- NIH Consortium grant - cross-NIH alliance [U54 EB020403]
- MRC [MR/R00465X/1, MR/N027558/1, MR/N000390/1] Funding Source: UKRI
Replicating results (i.e. obtaining consistent results using a new independent dataset) is an essential part of good science. As replicability has consequences for theories derived from empirical studies, it is of utmost importance to better understand the underlying mechanisms influencing it. A popular tool for non-invasive neuroimaging studies is functional magnetic resonance imaging (fMRI). While the effect of underpowered studies is well documented, the empirical assessment of the interplay between sample size and replicability of results for task-based fMRI studies remains limited. In this work, we extend existing work on this assessment in two ways. Firstly, we use a large database of 1400 subjects performing four types of tasks from the IMAGEN project to subsample a series of independent samples of increasing size. Secondly, replicability is evaluated using a multi-dimensional framework consisting of 3 different measures: (un)conditional test-retest reliability, coherence and stability. We demonstrate not only a positive effect of sample size, but also a trade-off between spatial resolution and replicability. When replicability is assessed voxelwise or when observing small areas of activation, a larger sample size than typically used in fMRI is required to replicate results. On the other hand, when focussing on clusters of voxels, we observe a higher replicability. In addition, we observe variability in the size of clusters of activation between experimental paradigms or contrasts of parameter estimates within these.
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