期刊
NEURAL DEVELOPMENT
卷 15, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13064-020-00143-9
关键词
Huwe1; EEL-1; Ubiquitin ligase; HECT; Neuron; Neural progenitor; Neurotransmission; Axon; Transcription factor; Intellectual disability
资金
- National Institutes of Health [R01 NS072129]
Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress made in deciphering how Huwe1 regulates neural progenitor proliferation and differentiation, cell migration, and axon development. We highlight recent evidence indicating that Huwe1 regulates inhibitory neurotransmission. In covering these topics, we focus on findings made using both vertebrate and invertebrate in vivo model systems. Finally, we discuss extensive human genetic studies that strongly implicate HUWE1 in intellectual disability, and heighten the importance of continuing to unravel how Huwe1 affects the nervous system.
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