期刊
CHEMICAL PHYSICS LETTERS
卷 661, 期 -, 页码 219-223出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cplett.2016.09.009
关键词
Biomimetic molecular systems; Bioinspired nanocatalyst; Protein-like copolymers; Radical copolymerization; Computer-aided design; Mesoscale simulations
资金
- Russian Science Foundation (RSF) [14-13-00544]
- Russian Science Foundation [14-13-00544] Funding Source: Russian Science Foundation
We present a new concept for designing biomimetic analogs of enzymatic proteins; these analogs are based on the synthetic protein-like copolymers. alpha-Chymotrypsin is used as a prototype of the artificial catalyst. Our experimental study shows that in the course of free radical copolymerization of hydrophobic and hydrophilic monomers the target globular nanostructures of a core-shell morphology appear in a selective solvent. Using a mesoscale computer simulation, we show that the protein-like globules can have a large number of catalytic centers located at the hydrophobic core/hydrophilic shell interface. (C) 2016 Elsevier B.V. All rights reserved.
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