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LEUKEMIA (2014)
Context-dependent control of alternative splicing by RNA-binding proteins
Xiang-Dong Fu et al.
NATURE REVIEWS GENETICS (2014)
AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer
Emmanuel S. Antonarakis et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Hallmarks of alternative splicing in cancer
S. Oltean et al.
ONCOGENE (2014)
Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans
Sina Mozaffari-Jovin et al.
RNA BIOLOGY (2014)
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Anoop P. Patel et al.
SCIENCE (2014)
Pharmacology of a Central Nervous System Delivered 2′-O-Methoxyethyl-Modified Survival of Motor Neuron Splicing Oligonucleotide in Mice and Nonhuman Primates
Frank Rigo et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)
Chemical Perturbation of Mcl-1 Pre-mRNA Splicing to Induce Apoptosis in Cancer Cells
Yang Gao et al.
ACS CHEMICAL BIOLOGY (2013)
Clinical implications of U2AF1 mutation in patients with myelodysplastic syndrome and its stability during disease progression
Shang-Ju Wu et al.
AMERICAN JOURNAL OF HEMATOLOGY (2013)
Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour regression
Hee Sook Lee et al.
BIOCHEMICAL JOURNAL (2013)
Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors
Ferry A. L. M. Eskens et al.
CLINICAL CANCER RESEARCH (2013)
Alternative splicing and retinal degeneration
M. M. Liu et al.
CLINICAL GENETICS (2013)
The development and application of small molecule modulators of SF3b as therapeutic agents for cancer
Thomas R. Webb et al.
DRUG DISCOVERY TODAY (2013)
Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome
Syed A. Mian et al.
HAEMATOLOGICA (2013)
RBM5, 6, and 10 Differentially Regulate NUMB Alternative Splicing to Control Cancer Cell Proliferation
Elias G. Bechara et al.
MOLECULAR CELL (2013)
Competition between Pre-mRNAs for the Splicing Machinery Drives Global Regulation of Splicing
Elizabeth M. Munding et al.
MOLECULAR CELL (2013)
Mutations and prognosis in primary myelofibrosis
A. M. Vannucchi et al.
LEUKEMIA (2013)
Mutational landscape and significance across 12 major cancer types
Cyriac Kandoth et al.
NATURE (2013)
Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
J. William Harbour et al.
NATURE GENETICS (2013)
Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway
L. Adesso et al.
ONCOGENE (2013)
MADD Knock-Down Enhances Doxorubicin and TRAIL Induced Apoptosis in Breast Cancer Cells
Andrea Turner et al.
PLOS ONE (2013)
SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma
Simon J. Furney et al.
CANCER DISCOVERY (2013)
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes
Felicitas Thol et al.
BLOOD (2012)
Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome
Su-Jiang Zhang et al.
BLOOD (2012)
SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival
Terra L. Lasho et al.
BLOOD (2012)
Cancer Vulnerabilities Unveiled by Genomic Loss
Deepak Nijhawan et al.
CELL (2012)
Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Marcin Imielinski et al.
CELL (2012)
BaxΔ2 Is a Novel Bax Isoform Unique to Microsatellite Unstable Tumors
Bonnie Haferkamp et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
SF3B1 mutations in primary myelofibrosis: clinical, histopathology and genetic correlates among 155 patients
T. L. Lasho et al.
LEUKEMIA (2012)
Clinical importance of SF3B1 mutations in Chinese with myelodysplastic syndromes with ring sideroblasts
Rui Cui et al.
LEUKEMIA RESEARCH (2012)
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
Timothy A. Graubert et al.
NATURE GENETICS (2012)
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
Victor Quesada et al.
NATURE GENETICS (2012)
The spliceosome as a target of novel antitumour drugs
Sophie Bonnal et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer
Jin Woo Choi et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2012)
Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC
Shipra Das et al.
CELL REPORTS (2012)
Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
Luca Malcovati et al.
BLOOD (2011)
WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing
Elianna M. Amin et al.
CANCER CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Silencing Survivin Splice Variant 2B Leads to Antitumor Activity in Taxane-Resistant Ovarian Cancer
Pablo E. Vivas-Mejia et al.
CLINICAL CANCER RESEARCH (2011)
Biological validation that SF3b is a target of the antitumor macrolide pladienolide
Akira Yokoi et al.
FEBS JOURNAL (2011)
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
Anna Corrionero et al.
GENES & DEVELOPMENT (2011)
The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region
Eric G. Folco et al.
GENES & DEVELOPMENT (2011)
Frequent pathway mutations of splicing machinery in myelodysplasia
Kenichi Yoshida et al.
NATURE (2011)
Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts
E. Papaemmanuil et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
Lili Wang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
A Short Caspase-3 Isoform Inhibits Chemotherapy-Induced Apoptosis by Blocking Apoptosome Assembly
Frederique Vegran et al.
PLOS ONE (2011)
The U2AF35-related protein Urp contacts the 3′ splice site to promote U12-type intron splicing and the second step of U2-type intron splicing
Haihong Shen et al.
GENES & DEVELOPMENT (2010)
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged
Charles J. David et al.
GENES & DEVELOPMENT (2010)
Anti-tumor activity of splice-switching oligonucleotides
John A. Bauman et al.
NUCLEIC ACIDS RESEARCH (2010)
Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia
Michal Stark et al.
BLOOD (2009)
EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma
Bipasha Mukherjee et al.
CANCER RESEARCH (2009)
The Spliceosome: Design Principles of a Dynamic RNP Machine
Markus C. Wahl et al.
CELL (2009)
MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death
Jae-Hong Kim et al.
FEBS LETTERS (2009)
Expression of ER-α36, a Novel Variant of Estrogen Receptor α, and Resistance to Tamoxifen Treatment in Breast Cancer
Liang Shi et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance
Doyel Mitra et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in Transgenic mice
Yimin Hua et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance
Ilaria Iacobucci et al.
BLOOD (2008)
Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists
Ying Wang et al.
CANCER RESEARCH (2008)
Role of IG20 splice variants in TRAIL resistance
Bellur S. Prabhakar et al.
CLINICAL CANCER RESEARCH (2008)
Alternative isoform regulation in human tissue transcriptomes
Eric T. Wang et al.
NATURE (2008)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
NATURE (2008)
The splicing-factor oncoprotein SF2/ASF activates mTORC1
Rotem Karni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Splicing segregation:: The minor spliceosome acts outside the nucleus and controls cell proliferation
Harald Koenig et al.
CELL (2007)
Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins
Graydon B. Gonsalvez et al.
JOURNAL OF CELL BIOLOGY (2007)
Control of alternative RNA splicing and gene expression by eukaryotic riboswitches
Ming T. Cheah et al.
NATURE (2007)
The gene encoding the splicing factor SF2/ASF is a proto-oncogene
Rotem Karni et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors
Hongbin Ji et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
EWS-ETS oncoproteins: The linchpins of Ewing tumors
R Janknecht
GENE (2005)
Mechanisms of cytoplasmic β-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase
XM Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-Related proteins CAPERα and CAPERβ
DH Dowhan et al.
MOLECULAR CELL (2005)
Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents
DR Mercatante et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia
ZG Ma et al.
NATURE GENETICS (2001)
Modification of alternative splicing of Bcl-x Pre-mRNA in prostate and breast cancer cells - Analysis of apoptosis and cell death
DR Mercatante et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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