期刊
NATURE MEDICINE
卷 26, 期 6, 页码 845-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41591-020-0897-1
关键词
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资金
- Emergency Project from the Science & Technology Commission of Chongqing
- Major National S&T Program grant from the Science & Technology Commission of China [2017ZX10202203, 2017ZX10302201]
- Division Of Computer and Network Systems
- Direct For Computer & Info Scie & Enginr [1702474] Funding Source: National Science Foundation
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [1717660] Funding Source: National Science Foundation
- Div Of Information & Intelligent Systems
- Direct For Computer & Info Scie & Enginr [1525919] Funding Source: National Science Foundation
- Russian Science Foundation [18-14-00325, 17-73-10408, 19-77-10007, 16-12-00004, 17-79-10456, 18-79-00078, 15-13-20021, 19-19-00623, 18-41-05003, 21-13-00038, 14-50-00005, 18-15-18003, 20-73-10007, 19-19-13022, 19-13-00411, 19-11-11008, 18-11-16003, 21-73-03010, 16-17-00104, 18-14-00293, 17-73-10251, 19-79-10162, 19-75-30032, 20-15-00057, 19-17-13026, 19-73-00171, 19-14-00026, 17-27-00010, 18-11-00044, 17-19-01522, 19-19-13037, 19-74-30014] Funding Source: Russian Science Foundation
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections. A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.
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