期刊
NATURE MEDICINE
卷 26, 期 5, 页码 681-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41591-020-0868-6
关键词
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资金
- Wellcome Sanger Institute [WT206194]
- Wellcome Strategic Scientific Support award 'Pilot projects for the Human Cell Atlas' [WT211276/Z/18/Z]
- Chan Zuckerberg Initiative
- European Union's H2020 Research and Innovation Program [874656]
- Newton Fund
- MRC
- Thailand Research Fund
- Thailand's National Science and Technology Development Agency
- GSK Ltd.
- Netherlands Lung Foundation [5.1.14.020, 4.1.18.226]
- HubMap consortium
- Stanford Child Health Research Institute-Woods Family Faculty Scholarship
- HubMap
- LENDULET-BIOMAG grant [2018-342]
- European Regional Development Fund [GINOP-2.3.2-15-2016-00006, GINOP-2.3.2-15-2016-00026, GINOP-2.3.2-15-2016-00037]
- UK Regenerative Medicine Platform [MR/5005579/1]
- Fondation pour la Recherche Medicale [DEQ20180339158]
- Agence Nationale de la Recherche (UCAJEDI) [ANR-15-IDEX-01]
- Agence Nationale de la Recherche (SAHARRA) [ANR-19-CE14-0027]
- Agence Nationale de la Recherche (France Genomique) [ANR-10-INBS-09-03]
- Conseil Departemental des Alpes Maritimes [2016-294DGADSH-CV, 2019-390DGADSH-CV]
- National Institutes of Health (NIH) [R01HL145372]
- DOD [W81XWH1910416, W81WH-16-2-0018]
- NIH [5R24HD000836, K08HL130595, R01HL127349, U01HL145567, HL135124, AG049665, AI135964, 5U24AI118672, U01 HL148856, DK043351, R01 HL135156, R01 MD010443, R01 HL128439, P01 HL132821, P01 HL107202, R01 HL117004]
- Eunice Kennedy Shriver National Institute of Child Health and Human
- Leducq foundation
- ERC Advanced grant
- Doris Duke Charitable Foundation
- Three Lakes Foundation
- National Research Foundation of Korea
- Wellcome Trust
- Rutherford Fund Fellowship
- Rosetrees Trust [M899]
- BHF/DZHK grant
- British Heart Foundation [PG/16/47/32156]
- Richard and Susan Smith Family Foundation
- Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center
- National Health
- NHLBI/NIH [R01HL146557]
- MRC [MR/P009581/1, MR/SO35907/1]
- German Research Foundation (DFG) [EXC2151/1, 390873048, 329123747, 347286815]
- HGF grant sparse2big
- Bill and Melinda Gates Foundation
- University College London, Birkbeck MRC Doctoral Training Programme
- National Key RD Program [2019YFA0801703]
- National Natural Science Foundation of China [31871370]
- NJH Regenerative Medicine and Genome Editing Program (REGEN)
- U.S. Department of Defense (DOD) [W81XWH1910416] Funding Source: U.S. Department of Defense (DOD)
- BBSRC [BB/V01126X/1, BB/T004460/1] Funding Source: UKRI
- EPSRC [TS/H001220/1] Funding Source: UKRI
- MRC [MR/S005579/1, MC_PC_17230, G0900879, MR/R015635/1, MR/P009581/1, MR/S035907/1, MR/R006237/1, MR/S035826/1, MR/S036334/1, G0701448] Funding Source: UKRI
- Medical Research Council [MR/S005579/1, MR/S035907/1, MR/P009581/1] Funding Source: researchfish
- Rosetrees Trust [M944, M899] Funding Source: researchfish
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
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