期刊
NATURE MEDICINE
卷 26, 期 6, 页码 842-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41591-020-0901-9
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资金
- Science and Technology Innovation Committee of Shenzhen Municipality [202002073000002]
- National Natural Science Foundation of China [91442127, 81700540]
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8(+) T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19. Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8(+) T cells in patients with moderate COVID-19.
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