期刊
NATURE CHEMISTRY
卷 12, 期 6, 页码 505-506出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41557-020-0479-3
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The direct conversion of lead compounds into potentially more potent derivatives, through selective functionalization, could help to speed up the discovery of drug candidates. Now, a method has been reported that enables the late-stage C-H methylation of complex drug-like molecules, using a sustainable cobalt-based catalyst.
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