期刊
NATURE CHEMISTRY
卷 12, 期 4, 页码 363-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41557-020-0444-1
关键词
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资金
- European Research Council
- EPSRC & BBSRC Centre for Doctoral Training in Synthetic Biology [EP/L016494/1]
- European Union [657650]
- US Army Research Office [W911NF-09-D-0001, W911NF-19-D-0001]
- Merton College
- Biotechnology and Biological Sciences Research Council [BB/M011224/1]
- OxSyBio
- Marie Curie Actions (MSCA) [657650] Funding Source: Marie Curie Actions (MSCA)
Responsive hydrogels that undergo controlled shape changes in response to a range of stimuli are of interest for microscale soft robotic and biomedical devices. However, these applications require fabrication methods capable of preparing complex, heterogeneous materials. Here we report a new approach for making patterned, multi-material and multi-responsive hydrogels, on a micrometre to millimetre scale. Nanolitre aqueous pre-gel droplets were connected through lipid bilayers in predetermined architectures and photopolymerized to yield continuous hydrogel structures. By using this droplet network technology to pattern domains containing temperature-responsive or non-responsive hydrogels, structures that undergo reversible curling were produced. Through patterning of gold nanoparticle-containing domains into the hydrogels, light-activated shape change was achieved, while domains bearing magnetic particles allowed movement of the structures in a magnetic field. To highlight our technique, we generated a multi-responsive hydrogel that, at one temperature, could be moved through a constriction under a magnetic field and, at a second temperature, could grip and transport a cargo.
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