期刊
NATURE CHEMICAL BIOLOGY
卷 16, 期 4, 页码 364-365出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41589-020-0503-3
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资金
- National Institutes of Health [R01AR075830]
- American Heart Association [19TPA34910051, 18TPA34230046]
Phospholipase D (PLD) regulates various cellular functions through the signaling lipid phosphatidic acid (PA). New crystal structures of human PLD1 and PLD2 reveal a catalytic mechanism, inhibitor binding, and regulation, enabling future structure-based inhibitor design and functional studies of PLD.
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