期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 1, 页码 136-141出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1768089
关键词
Senecio glaucus; aerial parts; benzofuran; antimicrobial; cytotoxicity
The ethyl acetate fraction of Senecio glaucusL. exhibited significant antimicrobial and cytotoxic activities, with a new compound showing potent antimicrobial effects against various microbes. The identified flavonoid compounds demonstrated moderate antimicrobial activities but no cytotoxic effects against cancer cell lines.
The ethyl acetate fraction of the dried aerial parts ofSenecio glaucusL. exhibited significant antimicrobial activity against some of selected bacteria and fungi. Also, it showed potent cytotoxicity against PANC-1 cancer cell lines under glucose deficient medium. The ethyl acetate fraction was subjected to different chromatographic techniques for isolation of the bioactive compounds. A new benzofuran glucoside; 2,3-dihydro-3 beta-hydroxyeuparin 3-O-glucopyranoside (1) was isolated. Additionally, two known flavonoid compounds isorhamentin 3-O-beta-D-glucoside (2), and isorhamentin 3-O-beta-D-rutinoside (3) were first identified inS. glaucus. Compound1exhibited potent antimicrobial activities against two Gram-positive bacteria, one Gram-negative bacteria, and two fungi. Also, it displayed potent cytotoxic activity against PANC-1 cancer cell lines under glucose deficient medium (IC50 7.5 mu M). However, the isolated flavonoid glycosides (2&3) showed moderate antimicrobial activities against two Gram-positive bacteria, two Gram-negative bacteria, four fungi, and did not show any cytotoxic activity against PANC-1.
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