期刊
NANOTECHNOLOGY
卷 31, 期 30, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/ab89d1
关键词
photodynamic therapy; redox reaction; nanocarriers; chemotherapy; synergistic anti-cancer therapy
资金
- National Natural Science Foundation of China [21574072, 21675091, 21874078]
- Taishan Young Scholar Program of Shandong Province [tsqn20161027]
- Key Research and Development Project of Shandong Province [2016GGX102028, 2016GGX102039, 2017GGX20111]
- Major Science and Technology Innovation Project of Shandong Province [2018CXGC1407]
- People's Livelihood Science and Technology Project of Qingdao [166257nsh, 173378nsh]
- Innovation Leader Project of Qingdao [168325zhc]
- Postdoctoral Scientific Research Foundation of Qingdao
- First Class Discipline Project of Shandong Province
Cancer treatment has always been a big problem for people. With the application of photodynamic therapy, the problem has been alleviated. However, the problem of tumor hypoxia affecting photodynamic therapy has been waiting to be resolved. Therefore, we report here that a redox nanocarrier (called RN) is prepared by hollow mesoporous silica sphere (HMSNs) and a redox-responsive polymer ligand. The nanocarrier is loaded with metformin and catalase, and the polymer is linked to the photosensitizer chlorin e6 (Ce6). Metformin inhibits the mitochondrial respiration of cancer cells, reducing the activity of cancer cells and increasing the oxygen concentration required for photodynamic therapy. Not only the effect of photodynamic therapy is enhanced, but also the effect of chemotherapy is increased to achieve super additive treatment. These RNs exhibit not only low cytotoxicity but also high biocompatibility in vitro experiments. In vitro Ce6 release studies have shown a higher release in the presence of glutathione (GSH). Confocal microscopy can further indicate that the nanoparticles are carried to the area around the nucleus of the cancer cells. In addition, treatment with a mouse tumor model demonstrated that RN has an effective therapeutic effect on tumors.
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