期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 28, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2020.102198
关键词
NIR II FL bioimaging; Targeting efficiency; Body clearance; Tumor surgery
资金
- National Key R&D Program of China [2016YFC1303103]
- Western Medicine Guide Project of Shanghai Municipal Commission of Science and Technology [17411960800]
- National Natural Science Foundation of China (NSFC) [61905248]
Failure of intraoperative detection, early minimal lesion and microscopic residual tumor margins elimination causes metastatic diffusion and lethal recurrence. However, during surgical process, surgeons can only rely largely on palpation and visual examination. Intraoperative bioimaging with the aid of the second near-infrared fluorescent (NIR II FL) light has entered the surgical excision area to bridge the gap of preoperative bioimaging and intraoperative resection. Here, we demonstrate that the follicle-stimulating hormone peptide (FSHP) engineered NIR II downshifting nanoparticles (DSNPs@FSHP) selectively undergo efficient ovarian tumor targeting property. Owing to the special biocompatibility of nanoprobes, this strategy provided rapid body clearance and efficient tumor targeting with significantly tumor to background (T/B) ratio enhanced for surgical excision. Based on these, this strategy can successfully empower the detection and surgical removal for both ovarian tumor lesions and ovarian tumor margins by NIR II FL bioimaging. (C) 2020 Elsevier Inc. All rights reserved.
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