期刊
NANO RESEARCH
卷 13, 期 8, 页码 2209-2215出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-020-2838-1
关键词
mesoporous silica; platinum nanoparticles; electrodynamic therapy; chemotherapy
类别
资金
- National Nature Science Foundation of China [51672247]
- '111' Program - Education Ministry of China and Sate Bureau of Foreign Experts Affairs [B16043]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Major State Research Program of China [2016YFC1101900]
- Provincial Key Research Program of Zhejiang Province [2020C04005]
- Fundamental Research Funds for the Central Universities
- ZJU-Hangzhou Global Scientific and Technological Innovation Center
Electrodynamic therapy (EDT) is a conceptually new cancer treatment approach recently proposed by our group. During EDT, the electro-driven catalytic reaction would occur on the surface of platinum nanoparticles (PtNPs) to produce reactive oxygen species (ROS) under the direct current (DC) or square-wave alternating current (AC) electric field. To further extend the potential of EDT, we hereby designed mesoporous silica-based nanocomposites decorated with PtNPs and loaded with anticancer drug doxorubicin (DOX) for synergistic electrodynamic-chemotherapy. Such silica-based nanocomposites could enable homogenous killing of large-sized tumors (over 500 mm3) and realize remarkable tumor destruction efficacy at a relatively low quantity of electricity. To our best knowledge, this is the first study to combine EDT and chemotherapy to develop a synergetic nanoplatform, openning a new dimension for the design of other EDT-based anticancer strategies.
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