期刊
NANO LETTERS
卷 20, 期 7, 页码 5383-5390出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c01729
关键词
biomedical engineering; molding; robotics; drug delivery; tissue sampling; genomics; proteomics
类别
资金
- National Science Foundation [NSF CMMI 1635443]
- National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (NIH) [R01EB017742]
Single cell manipulation is important in biosensing, biorobotics, and quantitative cell analysis. Although microbeads, droplets, and microrobots have been developed previously, it is still challenging to simultaneously excise, capture, and manipulate single cells in a biocompatible manner. Here, we describe untethered single cell grippers, that can be remotely guided and actuated on-demand to actively capture or excise individual or few cells. We describe a novel molding method to micropattern a thermally responsive wax layer for biocompatible motion actuation. The multifingered grippers derive their energy from the triggered release of residual differential stress in bilayer hinges composed of silicon oxides. A magnetic layer enables remote guidance through narrow conduits and fixed tissue sections ex vivo. Our results provide an important advance in high-throughput single cell scale biopsy tools important to lab-on-a-chip devices, microrobotics, and minimally invasive surgery.
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