期刊
NANO LETTERS
卷 20, 期 5, 页码 3754-3760出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c00755
关键词
Single-molecule; Nanopore sensing; DNA nanotechnology; DNA nanostructures; Molecular data storage
类别
资金
- ERC [647144]
- EPSRC [EP/M008258/1]
- George and Lilian Schiff Foundation Studentship
- Winton Programme for the Physics of Sustainability
- St John's Benefactors' Scholarship
- European Research Council (ERC) [647144] Funding Source: European Research Council (ERC)
- EPSRC [EP/M008258/1] Funding Source: UKRI
Nanopores are powerful single-molecule tools for label-tree sensing of nanoscale molecules including DNA that can be used for building designed nanostructures and performing computations. Here, DNA hard drives (DNA-HDs) are introduced based on DNA nanotechnology and nanopore sensing as a rewritable molecular memory system, allowing for storing, operating, and reading data in the changeable three-dimensional structure of DNA. Writing and erasing data are significantly improved compared to previous molecular storage systems by employing controllable attachment and removal of molecules on a long double-stranded DNA. Data reading is achieved by detecting the single molecules at the millisecond time scale using nanopores. The DNA-HD also ensures secure data storage where the data can only be read after providing the correct physical molecular keys. Our approach allows for easy-writing and easy-reading, rewritable, and secure data storage toward a promising miniature scale integration for molecular data storage and computation.
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