期刊
NANO LETTERS
卷 20, 期 6, 页码 4454-4463出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c01230
关键词
cancer nanovaccines; heat shock proteins; immunotherapy; cross-presentation; polymeric micelles
类别
资金
- National Natural Science Foundation of China [51933006, 21620102005, 81722026, 51603231, 51773099]
- National Key Research and Development Programs of China [2018YFA0209700]
- CAMS Innovation Fund for Medical Sciences [2016-I2M-3-022]
- Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019-RC-HL-014]
Inspired by heat shock proteins (HSPs), a self-assembly nanochaperone (nChap) is developed as a novel nanovaccine for boosting antitumor immune responses. Taking advantage of HSP-like microdomains and surface-decorated mannose, this nChap can efficiently capture antigens and ferry them into the dendritic cells (DCs). Subsequently, the nChap can blast lysosomes by transforming the structure and property of surface microdomains, thereby promoting antigen escape and enhancing their cross-presentation in cytoplasm. As a result, the nChap-based nanovaccine can elicit both CD4+ and CD8+ T cell-based immune responses and shows an excellent preventive effect on melanoma. Further combination of the nanovaccine with antiprogrammed death-1 (anti-PD-1) checkpoint blockade offers effective inhibition on the growth of already-established melanoma. Therefore, this nC ap-based nanovaccine provides a simple and robust strategy in mimicking HSPs to realize structure-assisted antigen capture, surface-receptor-mediated DC internalization, and both activation of humoral immunity and cellular immunity, promising for efficient cancer immunotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据