The multiple sclerosis prodrome: Emerging evidence, challenges, and opportunities

A prodrome is considered an early set of signs or symptoms indicating the onset of a disease or illness. In multiple sclerosis (MS), the prodromal period is the months or years before our current, classic understanding of MS symptom onset. Prodromal periods are well recognized in other neurodegenerative conditions and more recently have been shown in MS. In this Viewpoint, we reflect on the emerging evidence surrounding the MS prodrome, including features that may be common across chronic inflammatory and neurodegenerative diseases. Finally, we discuss the implications for future disease prevention in MS.

Automated summary

A prodrome is an early set of signs indicating the onset of a disease or illness, including in multiple sclerosis (MS) and other neurodegenerative conditions. Recognized in the months or years before classic symptom onset, prodromal periods may have implications for disease prevention in MS and other chronic inflammatory and neurodegenerative diseases.