期刊
MOLECULES
卷 25, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/molecules25081828
关键词
Julbernardia paniculata; Pterocarpus angolensis; ethnobotanical surveys; HPLC-DAD; GC-MS; phytochemicals; wound-healing activity
资金
- CICS-UBI - Fundacao para a Ciencia e a Tecnologia (FCT)
- Instituto Nacional de Gestao de Bolsas de Estudo (INAGBE) from Republica de Angola [459/2016]
- FCT [SFRH/BD/149360/2019]
- Centro de Competencias em Cloud Computing [CENTRO-01-0145-FEDER-000019-C4-403]
- Centro de Competencias em Cloud Computing (Fundo Europeu de Desenvolvimento Regional (FEDER) through the Programa Operacional Regional Centro (CENTRO 2020)) [UBIMEDICAL-CENTRO-01-0145-FEDER-000019-C4]
- CENTRO 2020 (C4 WP3.1-Data mining for systematic reviews and Meta-Analyses in Health Sciences)
- FCT
- Centro de Competencias em Cloud Computing (C4_WP2.6_M1-Bioinformatics)
- [UIDB/00709/2020]
- Fundação para a Ciência e a Tecnologia [UIDB/00709/2020] Funding Source: FCT
Julbernardia paniculata and Pterocarpus angolensis are two plant species with important application in African traditional medicine, particularly in Angola, in the treatment of several diseases. However, scientific studies concerning these species are scarce. The goal of this work was to know better which medicinal approaches are used by the Huila population in Angola by means of ethnobotanical surveys. Furthermore, extracts of both plants were phytochemically characterized. Antioxidant, anti-inflammatory, wound-healing activities, and potential cytotoxicity were also studied. With this study it was possible to verify that 67% of the individuals that use medicinal plants are women, and their main therapeutic uses are the treatment of problems of the digestive system and skin disorders. Barks of J. paniculata and leaves of P. angolensis are the most often used plant parts. Through high-performance liquid chromatography coupled to diode-array detector (HPLC-DAD) and GC-MS it was possible to characterize the chemical composition of the two species, which are rich in phenolic compounds, terpenes, terpenoids, sesquiterpenoids and fatty acids. Both plants showed to possess antioxidant, anti-inflammatory proprieties, and wound-healing activity. To the best of our knowledge, this is the most comprehensive study of these two species and the first ethnobotanical and ethnopharmacological study of medicinal plants from this region of Angola.
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