期刊
MOLECULES
卷 25, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/molecules25092178
关键词
photoprotection; bio-based chemicals; Meldrum's acid; UV-A; blue light; organic UV filters
资金
- EU's Horizon 2020 program [828753]
- Agence Nationale de la Recherche [ANR-17-CE07-0046]
- Conseil Departemental de la Marne
- Region Grand Est
- Grand Reims
Faced with the ban of some organic UV filters such as octinoxate or avobenzone, especially in Hawaii, it became essential to offer new alternatives that are both renewable and safe for humans and the environment. In this context, a class of bio-based molecules displaying interesting UV filter properties and great (photo)stability has been developed from Meldrum's acid and bio-based and synthetic p-hydroxycinnamic acids, furans and pyrroles. Moreover, p-hydroxycinnamic acid-based Meldrum's derivatives possess valuable secondary activities sought by the cosmetic industry such as antioxidant and anti-tyrosinase properties. The evaluation of the properties of mixture of judiciously chosen Meldrum's acid derivatives highlighted the possibility to modulate secondary activity while maintaining excellent UV protection. Meldrum's acid derivatives are not only competitive when benchmarked against organic filters currently on the market (i.e., avobenzone), but they also do not exhibit any endocrine disruption activity.
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