期刊
MOLECULES
卷 25, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/molecules25081853
关键词
branched gold nanoparticles; photothermal therapy; near-infrared (NIR) laser; MDA-MB-231 cell; mannose receptor
资金
- Ministry of Science and Technology of Taiwan [MOST 108-2113-M-005-004-, MOST 107-2320-B-037-005-MY3, KMU-DK 109006similar to4]
- National Chung Hsing University [MOST 108-2113-M-005-004-, MOST 107-2320-B-037-005-MY3, KMU-DK 109006similar to4]
- Kaohsiung Medical University [MOST 108-2113-M-005-004-, MOST 107-2320-B-037-005-MY3, KMU-DK 109006similar to4]
Recently, gold nanoparticles (Au NPs) have been used to study the treatment of malignant tumors due to their higher biocompatibility and lesser toxicity. In addition, they can be excited through a specific wavelength to produce oscillating plasmonic photothermal therapy (PPTT) on the basis of the localized surface plasma resonance (LSPR) effect. Au NPs can be heated to kill cancer cells in specific parts of the body in a noninvasive manner. In this study, branched gold nanoparticles (BAu NPs) were prepared by mixing HAuCl4 in a 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) buffer solution in a molar ratio of 1:2000. The UV-vis absorption peak was detected in the range of 700-1000 nm. Subsequently, BAu NPs were chemically linked to a thiol-modified mannoside molecule via a stable sulfur-Au covalent bond (Man@BAu NPs). Due to the presence of abundant mannose receptors on human-breast-cancer cells, MDA-MB-231, Man@BAu NPs were found to be abundant inside cancer cells. After irradiating the Man@BAu NP-laden MDA-MB231 switch with a near-infrared (NIR) laser at 808 nm wavelength, the photothermal-conversion effect raised the surface temperature of Man@BAu NPs, thus inducing cell death. Our experiment results demonstrated the advantages of applying Man@BAu NPs in inducing cell death in MDA-MB-231.
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