期刊
MOLECULES
卷 25, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/molecules25081931
关键词
chirality; chiral separations; preparative scale; liquid chromatography; supercritical fluid chromatography; counter-current chromatography; membranes; drug discovery; drug development
资金
- FCT-Foundation for Science and Technology [UID/Multi/04423/2019]
- European Regional Development Fund (ERDF) through the COMPETE-Programa Operacional Factores de Competitividade (POFC) program in the framework of the program PT2020
- COMPETE 2020, under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)
- project CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019
- [POCI-01-0145-FEDER-028736]
Enantiomeric separation is a key step in the development of a new chiral drug. Preparative liquid chromatography (LC) continues to be the technique of choice either during the drug discovery process, to achieve a few milligrams, or to a scale-up during the clinical trial, needing kilograms of material. However, in the last few years, instrumental and technical developments allowed an exponential increase of preparative enantioseparation using other techniques. Besides LC, supercritical fluid chromatography (SFC) and counter-current chromatography (CCC) have aroused interest for preparative chiral separation. This overview will highlight the importance to scale-up chiral separations in Medicinal Chemistry, especially in the early stages of the pipeline of drugs discovery and development. Few examples within different methodologies will be selected, emphasizing the trends in chiral preparative separation. The advantages and drawbacks will be critically discussed.
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