期刊
MOLECULES
卷 25, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/molecules25071631
关键词
absolute gas phase acidity; Fukui function; chemical potential; softness; nucleophile; electrophile; inductive effect; resonance effect; polarizability effect
资金
- Laboratorio Nacional de Supercomputo del Sureste de Mexico (LNS)
- Programa Especial de Apoyo a la Investigacion Basica UAM-2019
- [BUAP-CA-263]
A theoretical study of the effect of the substituent Z on the gas phase acidity of substituted benzoic acids ZC(6)H(4)COOH in terms of density functional theory descriptors (chemical potential, softness and Fukui function) is presented. The calculated gas phase Delta(acid)G degrees values obtained were close to the experimental ones reported in the literature. The good relationship between the Delta(acid)G degrees values and the electronegativity of ZC(6)H(4)COOH and its fragments, suggested a better importance of the inductive than polarizability contributions. The balance of inductive and resonance contributions of the substituent in the acidity of substituted benzoic acids showed that the highest inductive and resonance effects were for the -SO2CF3 and -NH2 substituents in the para- and ortho-position, respectively. The Fukui function confirmed that the electron-releasing substituent attached to the phenyl ring of benzoic acid decreased the acidity in the trend ortho > meta > para, and the electron-withdrawing substituent increased the acidity in the trend ortho < meta < para.
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