期刊
MOLECULES
卷 25, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/molecules25092096
关键词
bioanalysis; in-tube; solid phase microextraction; separation; sample preparation; review
In-tube solid phase microextraction is a cutting-edge sample treatment technique offering significant advantages in terms of miniaturization, green character, automation, and preconcentration prior to analysis. During the past years, there has been a considerable increase in the reported publications, as well as in the research groups focusing their activities on this technique. In the present review article, HPLC bioanalytical applications of in-tube SPME are discussed, covering a wide time frame of twenty years of research reports. Instrumental aspects towards the coupling of in-tube SPME and HPLC are also discussed, and detailed information on materials/coatings and applications in biological samples are provided.
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