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Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease
Dimitrios Kapogiannis et al.
LANCET NEUROLOGY (2011)
Emerging roles of mitochondrial proteases in neurodegeneration
Paola Martinelli et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
Ju-Hyun Lee et al.
CELL (2010)
S-Nitrosylation of DRP1 Does Not Affect Enzymatic Activity and is Not Specific to Alzheimer's Disease
Blaise Bossy et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Expression of β-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila
Xiao-Liang Zhao et al.
JOURNAL OF NEUROSCIENCE (2010)
Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex
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JOURNAL OF NEUROSCIENCE (2010)
Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort
Anita Lakatos et al.
NEUROBIOLOGY OF AGING (2010)
Association of Omi/HtrA2 with γ-secretase in mitochondria
Homira Behbahani et al.
NEUROCHEMISTRY INTERNATIONAL (2010)
Amyloid-beta-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons
Xinglong Wang et al.
NEURODEGENERATIVE DISEASES (2010)
Localization of HtrA2/Omi immunoreactivity in brains affected by Alzheimer's disease
Yasuhiro Kawamoto et al.
NEUROREPORT (2010)
A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
A. D. Roses et al.
PHARMACOGENOMICS JOURNAL (2010)
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
Heng Du et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria
Estela Area-Gomez et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Mitochondrial transport and docking in axons
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EXPERIMENTAL NEUROLOGY (2009)
A New Function of Human HtrA2 as an Amyloid-beta Oligomerization Inhibitor
Joel Kooistra et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment
Rukhsana Sultana et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2009)
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
Junko Wakabayashi et al.
JOURNAL OF CELL BIOLOGY (2009)
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Xinglong Wang et al.
JOURNAL OF NEUROSCIENCE (2009)
Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer's Disease
Kanae Iijima-Ando et al.
PLOS ONE (2009)
Distinct patterns of brain activity in young carriers of the APOE-ε4 allele
Nicola Filippini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mitochondrial protein homeostasis: the cooperative roles of chaperones and proteases
Wolfgang Voos
RESEARCH IN MICROBIOLOGY (2009)
S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Dong-Hyung Cho et al.
SCIENCE (2009)
Transcriptional control of mitochondrial biogenesis:: the central role of PGC-1α
Renee Ventura-Clapier et al.
CARDIOVASCULAR RESEARCH (2008)
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
Ann Cassidy-Stone et al.
DEVELOPMENTAL CELL (2008)
Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain
Changxing Shao et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions
Andreas Bender et al.
JOURNAL OF NEUROLOGY (2008)
Alzheimer's disease is associated with reduced expression of energy in posterior cingulate metabolism genes neurons
Winnie S. Liang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
Xinglong Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
Camilla A. Hansson Petersen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Differential regulation of dynein and kinesin motor proteins by tau
Ram Dixit et al.
SCIENCE (2008)
Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
Lisa Mosconi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Increased autophagic degradation mitochondria in Alzheimer disease
Paula I. Moreira et al.
AUTOPHAGY (2007)
Forecasting the global burden of Alzheimer's disease
Ron Brookmeyer et al.
ALZHEIMERS & DEMENTIA (2007)
Autophagocytosis of mitochondria is prominent in Alzheimer disease
Paula I. Moretra et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease
Wendy M. Brooks et al.
BRAIN RESEARCH (2007)
β-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease -: Implications for the physiological function of HtrA2 in the mitochondria
Hyo-Jin Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin et al.
NATURE (2006)
Acute impairment of mitochondrial trafficking by β-amyloid peptides in hippocampal neurons
Yanfang Rui et al.
JOURNAL OF NEUROSCIENCE (2006)
Degradation of the amyloid β-protein by the novel mitochondrial peptidasome, PreP
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
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JOURNAL OF NEUROSCIENCE (2006)
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
TZ Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
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ANNALS OF NEUROLOGY (2005)
Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease
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JOURNAL OF NEUROCHEMISTRY (2005)
Mitochondria, oxidants, and aging
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CELL (2005)
Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner
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CIRCULATION RESEARCH (2004)
Alzheimer's disease-associated amyloid beta interacts with the human serme protease HtrA2/Omi
HJ Park et al.
NEUROSCIENCE LETTERS (2004)
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
Z Li et al.
CELL (2004)
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
PE Coskun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Analysis of European mitochondrial haplogroups with Alzheimer disease risk
JM van der Walt et al.
NEUROSCIENCE LETTERS (2004)
The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease - Implications for early mitochonrial dysfunction and oxidative damage
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NEUROMOLECULAR MEDICINE (2004)
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
HK Anandatheerthavarada et al.
JOURNAL OF CELL BIOLOGY (2003)
Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Alzheimer disease
G Aliev et al.
NEUROTOXICITY RESEARCH (2003)
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
MT Lin et al.
HUMAN MOLECULAR GENETICS (2002)
Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD
DA Cottrell et al.
NEUROLOGY (2001)
Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: Superficial laminar cytochrome oxidase associated with disease duration
J Valla et al.
JOURNAL OF NEUROSCIENCE (2001)
Mitochondrial abnormalities in Alzheimer's disease
K Hirai et al.
JOURNAL OF NEUROSCIENCE (2001)
Alzheimer's disease: Genes, proteins, and therapy
DJ Selkoe
PHYSIOLOGICAL REVIEWS (2001)
Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease
G Carrieri et al.
HUMAN GENETICS (2001)
Oxidative stress inhibits the mitochondrial import of preproteins and leads to their degradation
G Wright et al.
EXPERIMENTAL CELL RESEARCH (2001)
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients
I Maurer et al.
NEUROBIOLOGY OF AGING (2000)