期刊
MOLECULAR BIOLOGY OF THE CELL
卷 31, 期 3, 页码 143-148出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E19-04-0207
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资金
- Centre National de la Recherche Scientifique
- Regional Council of Aquitaine
- University of Bordeaux through the Synthetic Biology in Bordeaux program (SB2)
- [ANR-13-BSV2-0015-01]
While the organization of inanimate systems such as gases or liquids is predominantly thermodynamically driven-a mixture of two gases will tend to mix until they reach equilibrium-biological systems frequently exhibit organization that is far from a well-mixed equilibrium. The anisotropies displayed by cells are evident in some of the dynamic processes that constitute life including cell development, movement, and division. These anisotropies operate at different length-scales, from the meso- to the nanoscale, and are proposed to reflect self-organization, a characteristic of living systems that is becoming accessible to reconstitution from purified components, and thus a more thorough understanding. Here, some examples of self-organization underlying cellular anisotropies at the cellular level are reviewed, with an emphasis on Rho-family GTPases operating at the plasma membrane. Given the technical challenges of studying these dynamic proteins, some of the successful approaches that are being employed to study their self-organization will also be considered.
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