4.8 Article

Rapid Accumulation of Mutations in Growing Mycelia of a Hypervariable Fungus Schizophyllum commune

期刊

MOLECULAR BIOLOGY AND EVOLUTION
卷 37, 期 8, 页码 2279-2286

出版社

OXFORD UNIV PRESS
DOI: 10.1093/molbev/msaa083

关键词

mutation rate; somatic mutation rate; Schizophyllum commune

资金

  1. Russian Science Foundation [16-14-10173]
  2. Russian Science Foundation [16-14-10173] Funding Source: Russian Science Foundation

向作者/读者索取更多资源

The basidiomycete Schizophyllum commune has the highest level of genetic polymorphism known among living organisms. In a previous study, it was also found to have a moderately high per-generation mutation rate of 2x10(-8), likely contributing to its high polymorphism. However, this rate has been measured only in an experiment on Petri dishes, and it is unclear how it translates to natural populations. Here, we used an experimental design that measures the rate of accumulation of de novo mutations in a linearly growingmycelium. We show that S. commune accumulatesmutations at a rate of 1.24x10(-7) substitutions per nucleotide per meter of growth, or similar to 2.04x10(-11) per nucleotide per cell division. In contrast to what has been observed in a number of species with extensive vegetative growth, this rate does not decline in the course of propagation of a mycelium. As a result, even a moderate per-cell-division mutation rate in S. commune can translate into a very high per-generation mutation rate when the number of cell divisions between consecutive meiosis is large.

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