期刊
MATRIX BIOLOGY
卷 91-92, 期 -, 页码 176-187出版社
ELSEVIER
DOI: 10.1016/j.matbio.2020.04.006
关键词
Matricryptins; Fibroblasts; Extracellular matrix; Peptides; Remodeling; Fibrosis
资金
- American Heart Association [18AIREA33960311]
- National Institutes of Health [R01 HL76246, R01 HL85440, R01 HL149407]
- U.S. Department of Defense [PR151134, PR151029, PR181464]
Alterations in the composition of the extracellular matrix (ECM) critically regulate the cellular responses in tissue repair, remodeling, and fibrosis. After injury, proteolytic degradation of ECM generates bioactive ECM fragments, named matricryptins, exposing cryptic sites with actions distinct from the parent molecule. Matricryptins contribute to the regulation of inflammatory, reparative, and fibrogenic cascades through effects on several different cell types both in acute and chronic settings. Fibroblasts play a major role in matricryptin generation not only as the main cellular source of ECM proteins, but also as producers of matrix-degrading pro-teases. Moreover, several matricryptins exert fibrogenic or reparative actions by modulating fibroblast phenotype and function. This review manuscript focuses on the mechanisms of matricyptin generation in injured and remodeling tissues with an emphasis on fibroblast-matricryptin interactions. (c) 2020 Elsevier B.V. All rights reserved.
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