期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.110683
关键词
Multifunctional nanoparticles; Realgar; Magnetite; Anticancer effect; Mechanochemistry
资金
- Slovak Research and Development Agency [APVV-18-0357]
- Slovak Grant Agency VEGA [2/0065/18, 2/0100/17, 1/0377/16]
- European Regional Development Fund [ITMS 26220120035]
Multifunctional nanoparticulate systems, especially those used in medicine, are currently of great interest. In this work, the in-vitro anticancer activity of As4S4/Fe3O4 composites dispersed in a water solution of Poloxamer 407 on breast MCF-7 and tongue SCC-25 cancer cells was verified. An increase in apoptotic cells as a consequence of higher caspase activities, a decrease in mitochondrial membrane potential and an accumulation of cells in the G2/M and subG0/G1 phases were detected after treatment with the As4S4/Fe3O4 nanosuspensions. The sterically stabilized nanosuspensions were characterized in relation to their particle size distribution, zeta potential and long-term stability properties. The interaction between the solid and liquid phases of the nanosuspensions was also studied using Fourier transform infrared spectroscopy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据