期刊
MARINE DRUGS
卷 18, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/md18040183
关键词
Junceella fragilis; fragilide; briarane; juncenolide; X-ray; iNOS; COX-2
资金
- National Museum of Marine Biology and Aquariums
- National Dong Hwa University
- Ministry of Science and Technology, Taiwan [MOST 1062320-B-291-001-MY3, 107-2320-B-291-001-MY3]
Two 11,20-epoxybriaranes, including a known compound, juncenolide K (1), as well as a new metabolite, fragilide X (2), have been isolated from gorgonian Junceella fragilis collected off the waters of Taiwan. The absolute configuration of juncenolide K (1) was determined by single-crystal X-ray diffraction analysis for the first time in this study and the structure, including the absolute configuration of briarane 2 was established on the basis of spectroscopic analysis and compared with that of model compound 1. One aspect of the stereochemistry of the known compound 1 was revised. Briarane 2 was found to enhance the generation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7 cells.
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