期刊
MACROMOLECULAR CHEMISTRY AND PHYSICS
卷 221, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.202000121
关键词
coil-g-rod graft copolymers; high drug-loading capacity; loose core; polymeric micelles; self-assembly
资金
- National Natural Science Foundation of China [51573049, 51833003, 51621002]
High drug loading capacity is one of the critical demands of micellar drug-delivery vehicles; however, it is a challenging work. Herein, it is demonstrated that micelles self-assembled from poly(ethylene glycol)-graft-poly(gamma-benzyl-l-glutamate) (PEG-g-PBLG) coil-g-rod graft copolymers display high drug-loading capacity for doxorubicin (DOX) model drugs. As revealed by a combination study of experiments and dissipative particle dynamics simulations, the high drug-loading capacity of the micelles is related to the loose core structure of the micelles. In these micelles, the hydrophobic PBLG grafts randomly disperse in the micelle core due to their rigid nature and the coil-g-rod topology of the graft copolymers, which results in a loose core of the micelles. The structure of the graft copolymer, including the length of rod grafts, the length of coil backbone, and the grafting ratio of the rod grafts affecting the arrangement of the rod grafts in the micelle core has influence on the drug-loading capacity of the micelles. Besides, the strong pi-pi stacking interaction between graft copolymers and DOX also plays an important part in achieving high drug-loading capacity. In vitro studies reveal that these drug-loaded micelles show good biocompatibility, and the DOX can be gradually released from the micelles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据