期刊
JOURNAL OF VIROLOGY
卷 94, 期 11, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00104-20
关键词
DC-SIGN; DC-SIGNR; flavivirus; West Nile virus; Zika virus; dengue virus; glycosylation
类别
资金
- [R21AI129431]
- [R01AI139512]
- [T32AI007419]
Flaviviruses encode one, two, or no N-linked glycosylation sites on their envelope proteins. Glycosylation can impact virus interactions with cell surface attachment factors and also may impact virion stability and virus replication. Envelope protein glycosylation has been identified as a virulence determinant for multiple flaviviruses, but the mechanisms by which glycosylation mediates pathogenesis remain unclear. In this Gem, we summarize current knowledge on flavivirus envelope protein glycosylation and its impact on viral infection and pathogenesis.
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