期刊
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
卷 113, 期 3, 页码 329-337出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jnci/djaa056
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资金
- Cancer Research UK [C1287/A16563, C1287/A10118, C1287/A10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565, C490/A10124, C490/A16561]
- European Union's Horizon 2020 Research and Innovation Programme [633784, 634935]
- European Communitys Seventh Framework Programme [223175, HEALTH-F2-2009-223175]
- NIH [U19 CA148065, CA192393, CA116167, CA176785, CA63464, CA54281, CA098758, CA132839, CA164973, CA97396, CA128931, CA116201, CA140286, CA177150, R01CA100374, P01 CA87969, UM1 CA186107, UM1 CA176726]
- Cancer UK [C1287/A16563]
- PERSPECTIVE project - Government of Canada through Genome Canada
- Canadian Institutes of Health Research [GPH-129344]
- Ministere de l'Economie, Science et Innovation du Quebec through Genome Quebec
- Quebec Breast Cancer Foundation
- European Community's Seventh Framework Programme [223175 (HEALTH-F2-2009-223175)]
- National Institutes of Health [CA128978, R01 CA77398, K05 CA136967, UM1 CA164917, U01 CA199277]
- Post-Cancer GWAS initiative [1U19 CA148537, 1U19 CA148065, 1U19 CA148112]
- Department of Defence [W81XWH-10-10341]
- Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer
- Komen Foundation for the Cure
- Breast Cancer Research Foundation
- Ovarian Cancer Research Fund
- National Cancer Institute (USA) [UM1 CA164920]
- National Health and Medical Research Council of Australia
- New South Wales Cancer Council
- Victorian Health Promotion Foundation (Australia)
- Victorian Breast Cancer Research Consortium
- Dutch Cancer Society [NKI 2007-3839, 2009 4363]
- Cancer Institute NSW
- National Breast Cancer Foundation
- intramural research program of the National Institutes of Health
- National Cancer Institute [Z01-CP010119, P50 CA058223, U54 CA156733, U01 CA179715]
- National Institute of Environmental Health Sciences [Z01-ES049030]
- ELAN-Fond of the University Hospital of Erlangen
- National Health and Medical Research Council, Australia
- Cancer Council Western Australia
- Accion Estrategica de Salud del Instituto de Salud Carlos III [FIS PI12/02125]
- Accion Estrategica de Salud del Instituto de Salud Carlos III FIS Intrasalud [PI13/01136]
- Programa Grupos Emergentes, Cancer Genetics Unit, Instituto de Investigacion Biomedica Galicia Sur
- Xerencia de Xestion Integrada de Vigo-SERGAS, Instituto de Salud Carlos III, Spain [10CSA012E]
- Conselleria de Industria Programa Sectorial de Investigacion Aplicada, PEME I+D e I+D Suma del Plan Gallego de Investigacion, Desarrollo e Innovacion Tecnologica de la Conselleria de Industria de la Xunta de Galicia, Spain [EC11-192]
- Grant FEDERInnterconecta. Ministerio de Economia y Competitividad, Xunta de Galicia, Spain
- Canadian Cancer Society [313404]
- Canadian Institutes of Health Research
- Fondation de France
- Institut National du Cancer (INCa)
- Ligue Nationale contre le Cancer
- Agence Nationale de Securite Sanitaire, de l'Alimentation, de l'Environnement et du Travail (ANSES)
- Agence Nationale de la Recherche (ANR)
- Chief Physician Johan Boserup and Lise Boserup Fund
- Danish Medical Research Council
- Herlev and Gentofte Hospital
- Instituto de Salud Carlos III
- Red Tematica de Investigacion Cooperativa en Cancer
- Asociacion Espanola Contra el Cancer
- Fondo de Investigacion Sanitario [PI11/00923, PI12/00070]
- American Cancer Society
- California Breast Cancer Act of 1993
- California Breast Cancer Research Fund [97-10500]
- California Department of Public Health as part of the statewide cancer reporting program [103885]
- Lon V Smith Foundation [LVS39420]
- European Commission (DG-SANCO)
- International Agency for Research on Cancer
- Ligue Contre le Cancer (France)
- Institut Gustave Roussy (France)
- Mutuelle Generale de l'Education Nationale (France)
- Institut National de la Sante et de la Recherche Medicale (INSERM) (France)
- German Cancer Aid (Germany)
- German Cancer Research Center (DKFZ) (Germany)
- Federal Ministry of Education and Research (BMBF) (Germany)
- Hellenic Health Foundation (Greece)
- Stavros Niarchos Foundation (Greece)
- Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy (Italy)
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare and Sports (VWS) (The Netherlands)
- Netherlands Cancer Registry (NKR) (The Netherlands)
- LK Research Funds (The Netherlands)
- Dutch Prevention Funds (The Netherlands)
- Dutch ZON (Zorg Onderzoek Nederland) (The Netherlands)
- World Cancer Research Fund (WCRF) (The Netherlands)
- Statistics Netherlands (The Netherlands)
- Health Research Fund (FIS) (Spain) [PI13/00061, PI13/01162]
- Regional Government of Andalucia (Spain)
- Regional Government of Asturias (Spain)
- Regional Government of Basque Country (Spain)
- Regional Government of Murcia (Spain)
- Regional Government of Navarra (Spain)
- ISCIII RETIC (Spain) [RD06/0020]
- Cancer Research UK (United Kingdom) [14136, C570/A16491, C8221/A19170]
- Medical Research Council (United Kingdom) [C8221/A19170, 1000143]
- Baden Wurttemberg Ministry of Science, Research and Arts
- German Cancer Aid (Deutsche Krebshilfe)
- Federal Ministry of Education and Research (BMBF) Germany [01KW9975/5, 01KW9976/8, 01KW9977/0, 01KW0114, 01KH0402]
- Robert Bosch Foundation, Stuttgart
- Deutsches Krebsforschungszentrum (DKFZ), Heidelberg
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
- Institute of the Ruhr University Bochum (IPA), Bochum
- Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany
- Deutsche Krebshilfe e. V. [70492, 70-2892-BR I, 106332, 108253, 108419, 110826, 110828]
- German Cancer Research Center (DKFZ)
- Marit and Hans Rausings Initiative Against Breast Cancer
- Queensland Cancer Fund
- Cancer Council of New South Wales
- Cancer Council of Victoria
- Cancer Council of Tasmania
- Cancer Council of South Australia
- Cancer Foundation of Western Australia
- United States Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- Cancer Council Victoria
- Cancer Council New South Wales
- Cancer Council South Australia
- Cancer Council Tasmania
- National Health and Medical Research Council of Australia (NHMRC) [400413, 400281, 199600]
- NHMRC
- Stichting tegen Kanker
- FWO
- Hamburg Cancer Society
- NIH Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201]
- VicHealth and Cancer Council Victoria
- Australian National Health and Medical Research Council [209057, 396414, 1074383]
- Swedish Cancer Society
- Swedish Research Council
- Local hospital funds
- Berta Kamprad Foundation
- Komen Foundation
- North Carolina University Cancer Research Fund
- Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services, USA
- Intramural Research Program of the National Institutes of Health, NCI, Division of Cancer Epidemiology and Genetics
- Intramural Research Program of the Division of Cancer Epidemiology and Genetics
- Division of Cancer Prevention, National Cancer Institute, National Institutes of Health
- NIHR [PGfAR 0707-10031]
- NIHR Biomedical Research Centre in Manchester [IS-BRC-1215-20007]
- Agency for Science, Technology and Research of Singapore (A*STAR)
- US National Institute of Health (NIH)
- Susan G. Komen Breast Cancer Foundation
- Sheffield Experimental Cancer Medicine Centre
- Breast Cancer Now Tissue Bank
- UK National Institute for Health Research Biomedical Research Centre at the University of Cambridge
- Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z01-ES044005, Z01-ES049033]
- Swedish Cancer Foundation
- Swedish Research Council [VR 2017-00644]
- Breast Cancer Now
- Institute of Cancer Research (ICR), London
- NHS
- National Heart, Lung, and Blood Institute
- US National Institutes of Health
- US Department of Health and Human Services [HHSN268201100046C, HHSN268201100001C, HHSN268201 100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C]
- NCI [U19 CA148065-01]
- [PSRSIIRI-701]
- [ERC-2011-294576]
- [P30 CA68485]
The study evaluated the joint associations between a new PRS313 and questionnaire-based breast cancer risk factors, revealing that the PRS313 odds ratio did not differ significantly across strata defined by individual risk factors. A multiplicative model assumption was adopted for breast cancer risk, and the variation in absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk.
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.
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