期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 20, 页码 9510-9517出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c03246
关键词
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资金
- University of Toronto
- Natural Science and Engineering Research Council (NSERC)
- Alphora/Eurofins
- Kennarshore, Inc.
- Walter C. Sumner Memorial Fellowship
- Province of Ontario
- Basque Government [IT908-16]
- UPV/EHU
- Government of Canada (NSERC-PGS)
An asymmetric hydroarylative cyclization of enynes involving a C-H bond cleavage is reported. The cobalt-catalyzed cascade generates three new bonds in an atom-economical fashion. The products were obtained in excellent yields and excellent enantioselectivities as single diastereo- and regioisomers. Preliminary mechanistic studies indicate that the reaction shows no intermolecular C-H crossover. This work highlights the potential of cobalt catalysis in C-H bond functionalization and enantioselective domino reactivity.
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