期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 16, 页码 7618-7626出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c01918
关键词
-
资金
- National Natural Science Foundation of China [21772161, 21622204, 91545105]
- Natural Science Foundation of Fujian Province of China [2019J02001]
- President Research Funds from Xiamen University [20720180036]
- NFFTBS [J1310024]
- PCSIRT
- Science & Technology Cooperation Program of Xiamen [3502Z20183015]
The generation of metal-containing 1,3-dipoles from metal carbenes represents a significant advance in 1,3-dipolar cycloaddition reactions. However, these transformations have so far been limited to reactions based on diazo compounds or triazoles as precursors. Herein, we disclose a copper-catalyzed enantioselective reaction of alkenyl N-propargyl ynamides with styrene derivatives by formal [3 + 2] cycloaddition via Cu-containing all-carbon 1,3-dipoles, which constitutes a novel way for the generation of metal-containing 1,3-dipoles via metal carbenes. This protocol allows the practical and atom-economical synthesis of valuable chiral pyrrole-fused bridged [2.2.1] skeletons in moderate to good yields (up to 90% yield) with excellent diastereoselectivities (dr > 50/1) and generally excellent enantioselectivities (up to >99% ee).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据