期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 11, 页码 5355-5361出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c00245
关键词
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资金
- Foundation for Polish Sciences [FNP TEAM POIR.04.04.00-00-4232/17-00]
- National Science Center [2018/28/T/ST5/00162]
Strain-release-driven methodology is a powerful tool for accessing structural motifs, highly desirable by the pharmaceutical industry. The reactivity of spring-loaded cyclic reagents is dominated by transformations relying on their inherent electrophilic reactivity. Herein, we present a polarity-reversal strategy based on light-driven cobalt catalysis, which enables the generation of nucleophilic radicals through strain release. The applicability of this methodology is demonstrated by the design of two distinct types of reactions: Giese-type addition and Co/Ni-catalyzed cross-coupling. Moreover, a series of electrochemical, spectroscopic, and kinetic experiments as well as X-ray structural analysis of the intermediate alkylcobalt(III) complex give deeper insight into the mechanism of the reaction.
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