Preparation as Well as Evaluation of the Nanofiber Membrane Loaded with Nigella sativa Extract Using the Electrospinning Method

In the present study, the edible and biodegradable Zein microfiber is prepared using the glacial acetic acid solvent and electrospinning approach. It is possible to produce uniform nanofibers without bead by changing several parameters such as the concentrations of Zein and drug, gap between the needle tip and collector, electrospinning voltage and solution's flow rate. Here, the solution of Zein and black seed (Nigella sativa) oil has been produced and electrospun at three different oil concentrations of 5, 10 and 15% w/v. The electrospinning voltage, gap between the needle tip and collector and flow rate were kept fixed for these three concentration levels as 20 kV, 15 cm and 4 mL/h, respectively. According to the obtained results, the concentration variation of the black seed oil has a significant effect (P <= 0.05) on the fiber diameter in such a way that fiber diameter increases with an increment in the oil concentration. Further aim of the present study is to prepare as well as evaluate the membrane properties of Zein nanofibers containing black seed oil using the electrospinning method for modern drug delivery uses.