期刊
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
卷 11, 期 13, 页码 4951-4957出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.0c01138
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资金
- National Research Foundation of Singapore [NRF2015NRF-POC0001-19]
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [2020R1C1C1004385]
- Korea Research Fellowship Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2019H1D3A1A01070318]
Using quartz crystal microbalance-dissipation and time-lapse fluorescence microscopy, we demonstrate that adding mixtures of lauric acid (LA) and glycerol monolaurate (GML), two of the most biologically active antimicrobial fatty acids and monoglycerides, to a supported lipid bilayer triggers concurrent tubule and bud formation, which unexpectedly results in synergistic phospholipid membrane remodeling that far exceeds the effects of GML or LA alone. Together, GML and LA drive pearling instability, dynamic transformation of buds into tubules and vice versa, and extensive membrane lysis. The most pronounced effects occurred with equimolar concentrations of GML and LA, highlighting that synergistic membrane disruption arises from competition for the lipid supply to buds and tubules and an inability to relieve membrane strains. These findings offer a conceptually new model to explain how fatty acid and monoglyceride interactions can trigger phospholipid membrane remodeling events relevant to various biophysical and biological systems.
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