4.3 Article

A trial comparing continuous positive airway pressure (CPAP) devices in preterm infants

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JOURNAL OF PERINATOLOGY
卷 40, 期 8, 页码 1193-1201

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NATURE PUBLISHING GROUP
DOI: 10.1038/s41372-020-0690-5

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  1. Seattle Children's Research Institute (Seattle, WA)
  2. Bill & Melinda Gates Foundation [OPP1094124]
  3. Bill and Melinda Gates Foundation [OPP1094124] Funding Source: Bill and Melinda Gates Foundation

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Objective To test the hypothesis that infants born <30 weeks' gestation supported by Seattle-PAP will have lower rates of continuous positive airway pressure (CPAP) failure than infants supported with conventional, Fisher&Paykel-CPAP (FP-CPAP). Study design Randomized trial (3/2017-01/2019) at 5 NICUs. The primary outcome was CPAP failure; subgroup analyses (gestational age, receipt antenatal corticosteroids) were performed. Results A total of 232 infants were randomized. Infants in the Seattle-PAP and FP-CPAP groups had mean gestational ages of 27.0 and 27.2 weeks, respectively. We observed no differences in rates of treatment failure between Seattle-PAP (40/112, 35.7%) and FP-CPAP (38/120, 31.7%; risk difference, 4.1%; 95% CI, -8.1-16.2; P = 0.51). Subgroup analysis indicated no differences in rates of CPAP failure. We observed no differences between the two groups in frequencies of adverse events or duration of respiratory support. Conclusions Among infants born <30 weeks' gestation, rates of CPAP failure did not differ between Seattle-PAP and FP-CPAP.

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