4.7 Article

A lysosome-targeted fluorescent sensor for the detection of glutathione in cells with an extremely fast response

期刊

CHEMICAL COMMUNICATIONS
卷 52, 期 77, 页码 11579-11582

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc06750f

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资金

  1. National Science Fund for Distinguished Young Scholars of China [21225313]
  2. National Natural Science Foundation of China [21303126, 21573168, 21673166]
  3. Natural Science Foundation of Hubei Province [2014CFA003]
  4. Large-Scale Instrument and Equipment Sharing Foundation of Wuhan University

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A highly sensitive and selective Rhodamine B-based fluorescent sensor, RhB-1, for glutathione (GSH) was easily synthesized. An extremely fast detection response time of 10 s, which is the fastest one ever reported, is achieved in aqueous solutions over a wide pH range with large enhancement of emission intensity. The sensor detects GSH in cells and selectively accumulates in lysosomes.

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