期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 85, 期 11, 页码 7485-7493出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c00975
关键词
-
资金
- National Natural Science Foundation of China [21272136]
- China Three Gorges University
Direct N-glycosylation between glycals and amides/amines was achieved with exclusive stereoselectivity in moderate to high yields. Various amides, amines, and 3,4-O-carbonate-glycals were tolerated, and unique beta-N-glycosides were obtained. The strategy was based on palladium-catalyzed decarboxylative allylation, and the high 1,4-cis-selectivity was proposed because of the hydrogen bonding effect. Notably, all the synthesized products were subjected to preliminary bioactivity studies, revealing that three compounds were cytotoxic to tumor cells and nontoxic to normal human cells.
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