Benzylic Hydroperoxidation via Visible-Light-Induced Csp3-H Activation

A highly efficient benzylic hydroperoxidation has been realized through a visible-light-induced Csp(3)-H activation. We believe that this reaction undergoes a direct HAT mechanism catalyzed by eosin Y. This approach features the use of a metal-free catalyst (eosin Y), an energy-economical light source (blue LED), and a sustainable oxidant (molecular oxygen). Primary, secondary, and tertiary hydroperoxides as well as silyl, benzyl, and acyl peroxides were successfully prepared with good yields and excellent functional group compatibility.