期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 83, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2020.108429
关键词
Adipose tissue; Catechins; Energy expenditure; Obesity; Polyphenols
资金
- Sao Paulo Research Foundation (FAPESP) [2015/07024-8, 2013/22293-0, 2012/20415-8, 2011/19216-8]
- Cruzeiro do Sul University
The potential contribution of green tea (GT) to the development of thermogenic/beige cells have been scarcely investigated. Here we investigated if the beneficial effects of GT in the induction of thermogenic/beige adipocytes results from an initial cell commitment during adipogenesis. Male C57Bl/6 mice (3 months) were divided into 3 groups: Control (chow diet), Obese (cafeteria diet), and Obese + GT. Mice received GT gavage (500 mg/kg of BW) over 12 weeks (5 days/week), after 4 weeks of diet, totalizing 16 weeks of experimentation. GT treatment increased energy expenditure (EE) in mice fed with cafeteria-diet leading to reduced BW gain, decreased adiposity, reduced inflammation, and improving insulin sensitivity. Those phenotypes were associated with enhanced expression of oxidative, thermogenic and beige genes. GT induced a futile cycle through de novo lipogenesis activating the thermogenic pathway. Induction of beige phenotype occurs autonomously in adipocytes and involves the PPAR gamma/FGF21/AMPK/UCP1 pathway. Our study identified that metabolic changes caused by GT may involve the temporal expression of PPAR gamma promoting the induction of thermogenic cells by reprogramming initial steps of adipocyte commitment. (C) 2020 Elsevier Inc. All rights reserved.
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