期刊
JOURNAL OF NEUROSCIENCE
卷 40, 期 24, 页码 4673-4684出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2682-19.2020
关键词
correlation; sleep; spiking; spindle; slow waves; slow oscillations
资金
- Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service Award [1I01RX001640-01A1]
- National Institute of Neurological Disorders and Stroke of the National Institutes of Health Award [K02NS093014]
- National Institutes of Health BRAIN Initiative Award [NS094375]
- National Science Foundation Graduate Research Fellowship
- American Heart Association Predoctoral Fellowship
Spindles and slow oscillations (SOs) both appear to play an important role in memory consolidation. Spindle and SO nesting, or the temporal overlap between the two events, is believed to modulate consolidation. However, the neurophysiological processes modified by nesting remain poorly understood. We thus recorded activity from the primary motor cortex of 4 male sleeping rats to investigate how SO and spindles interact to modulate the correlation structure of neural firing. During spindles, primary motor cortex neurons fired at a preferred phase, with neural pairs demonstrating greater neural synchrony, or correlated firing, during spindle peaks. We found a direct relationship between the temporal proximity between SO and spindles, and changes to the distribution of neural correlations; nesting was associated with narrowing of the distribution, with a reduction in low- and high-correlation pairs. Such narrowing may be consistent with greater exploration of neural states. Interestingly, after animals practiced a novel motor task, pairwise correlations increased during nested spindles, consistent with targeted strengthening of functional interactions. These findings may be key mechanisms through which spindle nesting supports memory consolidation.
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