NIR light/H2O2-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells

In this work, smart near-infrared (NIR) light/H2O2-triggered and O-2-evolving nanocomposites were designed and applied for efficient production of O-1(2) by converting a deeply penetrating NIR light into a visible light to excite the photosensitizers and achieve a self-sufficiency of the O-2 generation in the photodynamic therapy process to overcome the hypoxia-induced drug resistance.