Levodopa challenge test: indications, protocol, and guide

A drug challenge test in Parkinson's disease, such as the levodopa challenge test (LCT), is an easy and generally safe procedure, which has been used by clinicians for various indications. The results of the test have significant implications in the management of patients, from preoperative evaluation for deep brain stimulation to providing the basis for medication adjustments to address motor or non-motor fluctuations and dyskinesias. This paper reviews the different indications and protocols commonly used in an acute LCT. Potential complications of the procedure and an overview of levodopa responsiveness and unresponsiveness are also discussed.

Automated summary

This paper discusses the importance of drug challenge test in Parkinson's disease, especially the levodopa challenge test, and provides an overview of the different indications, commonly used protocols, and responsiveness or unresponsiveness to levodopa. Potential complications of the procedure are also highlighted.