期刊
JOURNAL OF NATURAL PRODUCTS
卷 83, 期 4, 页码 1152-1156出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b01185
关键词
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资金
- National Key Research and Development Program [2018YFC1406705]
- National Natural Science Foundation of China [31630004, 41676165]
- Chinese Academy of Sciences [QYZDJ-SSW-DQC004]
Overexpression of phosphopantetheinyl transferase (PPtase)- encoding genes sfp and svp in the marine-derived Verrucosispora sp. SCSIO 40062 led to the production of two new aminofuran monomers, proximicin F (1) and proximicin G (3) and a new dimer diproximicin A (2), along with two known compounds, proximicins B (4) and C (5). Their structures were unambiguously elucidated on the basis of detailed NMR spectroscopic analysis and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. Proximicin B (4) showed moderate antibacterial activities against Staphylococcus aureus, methicillin-resistant S. aureus, and Bacillus subtilis.
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